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Mussel‐Inspired Coating of Polydopamine Directs Endothelial and Smooth Muscle Cell Fate for Re‐endothelialization of Vascular Devices

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WOS被引频次:68
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成果类型:
期刊论文
作者:
Yang, Zhilu;Tu, Qiufen;Zhu, Ying;Luo, Rifang;Li, Xin;Xie, Yichu;Maitz, Manfred F.;Wang, Jin*;Huang, Nan
通讯作者:
Wang, Jin
作者机构:
[Zhu, Ying; Xie, Yichu; Luo, Rifang; Yang, Zhilu; Tu, Qiufen; Huang, Nan; Wang, Jin; Li, Xin] SW Jiaotong Univ, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China.
[Maitz, Manfred F.; Yang, Zhilu; Huang, Nan] SW Jiaotong Univ, Inst Biomat & Surface Engn, Chengdu 610031, Peoples R China.
[Tu, Qiufen] SW Jiaotong Univ, Lab Biosensing & MicroMechatron, Chengdu 610031, Peoples R China.
[Maitz, Manfred F.] Max Bergmann Ctr Biomat Dresden, Leibniz Inst Polymer Res Dresden, D-01069 Dresden, Germany.
通讯机构:
[Wang, Jin] SW Jiaotong Univ, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China.
语种:
英文
关键词:
endothelial cells;hemocompatibility;polydopamine;smooth muscle cells;stents
期刊:
Advanced Healthcare Materials
ISSN:
2192-2659
年:
2012
卷:
1
期:
5
页码:
548-559
文献类别:
WOS:Article;PUBMED:Journal Article
入藏号:
基金类别:
National Natural Science Foundation of China [51173149, 30831160509]; Ministry of Science and Technology of China [2011CB606204]; China Natural Science Foundation for the Youth [31000426, 30900295]; Fundamental Research Funds for the Central Universities [SWJTU11CX130, SWJTU11CX057]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
Polydopamine (PDAM), a mussel adhesive protein inspired coating that can be easily deposited onto a wide range of metallic, inorganic, and organic materials, gains interest also in the field of biomaterials. In this work, PDAM is applied as coating on 316L stainless steel (SS) stents and the response of cells of the blood vessel wall, human umbilical vein endothelial cell (HUVEC), and human umbilical artery smooth muscle cell (HUASMC) as predictors for re‐endothelialization is tested. It is found that the PDAM‐modified surface significantly enhances HUVEC adhesion, proliferation, and migration, release of nitric oxide (NO), and secretion of prostaglandin I2 (PGI2). Additionally, the PDAM‐modified surface shows a remarkable ability to decrease the adhesion and proliferation of HUASMCs. As a blood‐contacting material, the PDAM tends to improve the hemocompatibility compared with the substrate 316L SS. It is noteworthy that the PDAM coating shows good resistance to the deformation behavior of compression and expansion of a stent. These data suggest the potential of PDAM as a blood‐contacting material for the application in vascular stents or grafts.
参考文献:
Agnihotri A, 2009, COLLOID SURFACE B, V71, P138, DOI 10.1016/j.colsurfb.2009.01.019
Anderson SM, 2009, BIOMATERIALS, V30, P4618, DOI 10.1016/j.biomaterials.2009.05.030
Avci-Adali M, 2008, BIOMATERIALS, V29, P3936, DOI 10.1016/j.biomaterials.2008.07.002
Besch W, 2008, PLASMA PROCESS POLYM, V5, P105, DOI 10.1002/ppap.200700104
Chen HM, 2009, CANCER LETT, V286, P161, DOI 10.1016/j.canlet.2009.05.040

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