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Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor

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WOS被引频次:150
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成果类型:
期刊论文
作者:
Yang, Ye;Xia, Tian;Zhi, Wei;Wei, Li;Weng, Jie;Zhang, Cong;Li, Xiaohong
通讯作者:
Li, X.(xhli@swjtu.edu.cn)
作者机构:
[Zhang, Cong; Xia, Tian; Wei, Li] Department of Pathology, The 452th Hospital of People's Liberation Army, Chengdu 610021, China
[Weng, Jie; Zhang, Cong; Yang, Ye; Zhi, Wei; Li, Xiaohong] Key Laboratory of Advanced Technologies of Materials, Ministry of Education of China, Southwest Jiaotong University, School of Materials Science and Engineering, Chengdu 610031, China
[Yang, Ye] School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230031, China
通讯机构:
[Li, XH] SW Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ China, Key Lab Adv Technol Mat, Chengdu 610031, Peoples R China.
语种:
英文
关键词:
After-treatment - Basic fibroblast growth factor - Burst release - Capillary vessel - Collagen deposition - Collagen fiber - Core-sheath structures - Diabetic rats - Diabetic ulcer - Electrospun fibrous mats - Electrospuns - Extracellular matrices - Functional properties - Growth factor-loaded fibrous mats - Histological section - In-vitro - In-vivo - Molecular signals - Mouse embryo fibroblasts - Normal tissue - Re-epithelialization - Recovery rate - Skin regeneration - Ultra-fine fibers - Wound healing process - Wound repair
期刊:
Biomaterials
ISSN:
0142-9612
年:
2011
卷:
32
期:
18
页码:
4243-4254
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:材料科学;WOS学科类别:Engineering, Biomedical;Materials Science, Biomaterials
入藏号:
WOS:000291171600009;EI:20111713938740;PMID:21402405
基金类别:
National Natural Science Foundation of China [20774075, 51073130]; Fok Ying Tong Education Foundation [104032]; Ministry of Education of China
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
Diabetic skin ulcer is difficult to heal due to the lack of cellular and molecular signals required for normal wound repair. Emulsion electrospinning was adopted to imbed basic fibroblast growth factor (bFGF) into ultrafine fibers with a core-sheath structure to promote the wound healing process. An initially burst release as low as 14.0 +/- 2.2% was achieved, followed by gradual release for around 4 wk. In vitro investigations on mouse embryo fibroblasts indicated that bFGF-loaded fibrous mats enhanced cell adhesion, proliferation, and secretion of extracellular matrix (ECM). Skin wounds were created in the dorsal area of diabetic rats for in vivo evaluation of skin regeneration after covered with bFGF-loaded fibrous mats. Compared with fibrous mats infiltrated with free bFGF, bFGF-loaded scaffolds revealed significantly higher wound recovery rate with complete re-epithelialization and regeneration of skin appendages. Higher density and mature capillary vessels were generated during 2 wk after treatment with bFGF-loaded fibers, and there was no fiber fragment observed in the histological sections at week 4 after operation. The gradual release of bFGF from fibrous mats enhanced collagen deposition and ECM remodeling, and the arrangement and component of collagen fibers were similar to normal tissues. The above results demonstrate the potential use of bFGF-loaded electrospun fibrous mats to rapidly restore the structural and functional properties of wounded skin for patients with diabetic mellitus. (C) 2011 Elsevier Ltd. All rights reserved.
参考文献:
Arima Y, 2007, BIOMATERIALS, V28, P3074, DOI 10.1016/j.biomaterials.2007.03.013
Blakytny R, 2006, DIABETIC MED, V23, P594, DOI 10.1111/j.1464-5491.2006.01773.x
Bryan D, 2005, CYTOKINE, V31, P429, DOI 10.1016/j.cyto.2005.06.015
CLARK RAF, 1985, J AM ACAD DERMATOL, V13, P701, DOI 10.1016/S0190-9622(85)70213-7
Cui WG, 2008, POLYM DEGRAD STABIL, V93, P731, DOI 10.1016/j.polymdegradstab.2007.12.002

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