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The role of heparin binding surfaces in the direction of endothelial and smooth muscle cell fate and re-endothelialization

Medline
WOS被引频次:71
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成果类型:
期刊论文
作者:
Yang, Zhilu*;Tu, Qiufen;Wang, Jin;Huang, Nan
通讯作者:
Yang, Zhilu
作者机构:
[Yang, Zhilu; Tu, Qiufen; Huang, Nan; Wang, Jin] SW Jiaotong Univ, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China.
[Yang, Zhilu; Huang, Nan] SW Jiaotong Univ, Inst Biomat & Surface Engn, Chengdu 610031, Peoples R China.
[Tu, Qiufen] SW Jiaotong Univ, Lab Biosensing & MicroMechatron, Chengdu 610031, Peoples R China.
通讯机构:
[Yang, Zhilu] SW Jiaotong Univ, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China.
语种:
英文
关键词:
Heparin;Endothelial cells;Smooth muscle cells;Anticoagulation;Vascular devices
期刊:
Biomaterials
ISSN:
0142-9612
年:
2012
卷:
33
期:
28
页码:
6615-6625
文献类别:
WOS:Article;PUBMED:Journal Article
入藏号:
基金类别:
National Natural Science Foundation of China [51173149, 30831160509]; Ministry of Science and Technology of China [2011CB606204]; China Natural Science Foundation for the Youth [31000426, 30900295]; Fundamental Research Funds for the Central Universities [SWJTU11CX130, SWJTU11CX057]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
In this work, the effects of a heparin-functionalized coating on the growth behavior of vascular cells were studied. To retain its functionality, heparin was bound to a cationic plasma polymerized allylamine coating through electrostatic interaction. The heparin binding surface significantly inhibited human umbilical artery smooth muscle cell (HUASMC) adhesion and proliferation. In contrast, human umbilical vein endothelial cells (HUVECs) showed significant enhancement in cell adhesion, proliferation and migration, release of nitric oxide (NO) and secretion of prostaglandin I-2 (PGI(2)). The test of acute thrombogenicity assessed using human blood exhibited an excellent antithrombotic performance of the heparin grafted surface. The heparinized surface significantly promoted in vivo re-endothelialization and effectively inhibited thrombosis formation. These observations form an important framework for further deciphering the biological functions of heparin. It is highlighted that these striking findings may serve as a guide for the design of multifunctional vascular devices. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
参考文献:
ABRO A, 1975, EXPERIENTIA, V31, P1453
Avci-Adali M, 2008, BIOMATERIALS, V29, P3936, DOI 10.1016/j.biomaterials.2008.07.002
AZIZKHAN RG, 1980, J EXP MED, V152, P931, DOI 10.1084/jem.152.4.931
Bartorelli AL, 1997, CATHETER CARDIO DIAG, V42, P313, DOI 10.1002/(SICI)1097-0304(199711)42:3<313::AID-CCD21>3.0.CO
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