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Modulating cellular behaviors through surface nanoroughness

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WOS被引频次:27
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成果类型:
期刊论文
作者:
Luo, Chao;Li, Long;Li, Jinrong;Yang, Guang;Ding, Shan;Zhi, Wei;Weng, Jie;Zhou, Shaobing*
通讯作者:
Zhou, Shaobing
作者机构:
[Ding, Shan; Luo, Chao; Zhou, Shaobing; Li, Jinrong] SW Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China.
[Yang, Guang; Zhi, Wei; Li, Long; Zhou, Shaobing; Weng, Jie] SW Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China.
通讯机构:
[Zhou, Shaobing] SW Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China.
语种:
英文
期刊:
Journal of Materials Chemistry
ISSN:
0959-9428
年:
2012
卷:
22
期:
31
页码:
15654-15664
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:材料科学;WOS学科类别:Chemistry, Physical;Materials Science, Multidisciplinary
入藏号:
WOS:000306479600029;EI:20123015273425
基金类别:
National Basic Research Program of China (973 Program) [2012CB933602]; National Natural Science Foundation of China [30970723, 51173150]; Fundamental Research Funds for The Central Universities [SWJTU11ZT10]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
The influence of nanoscale surface topographical features on cell functions has attracted more and more attention in the last few years. Herein, the surface nanoroughness on a nanofiber membrane was engineered with an electrospinning approach by simply adjusting the concentration of the polymer solution. The surface topographical features were characterized with scanning electron microscopy (SEM) and atomic force microscopy (AFM). The impact of different surface nanoroughness on cellular behavior was further investigated from cell adhesion, spreading, proliferation and differentiation, through co-culturing with rat bone marrow mesenchymal stem cells (rBMSCs). Investigation of the effect of surface nanoroughness on subcutaneous bone formation in vivo was also performed, and a histological section was dyed with H&E and Masson's trichrome staining. The distinctive acquired result shows that the existence of beads on electrospun nanofibers does not bring any negative effect on cell growth, and moreover the moderate surface nanoroughness can modulate and facilitate cellular behaviors compared with the smooth surface. Therefore, we think that the electrospun nanofibers with suitable nanoroughness can have great potential for biomedical applications as a tissue engineering scaffold. ©2012 The Royal Society of Chemistry.
参考文献:
Andersson AS, 2003, BIOMATERIALS, V24, P3427, DOI 10.1016/S0142-9612(03)00208-4
Anselme K, 2010, ACTA BIOMATER, V6, P3824, DOI 10.1016/j.actbio.2010.04.001
Chen SL, 2010, BIOMATERIALS, V31, P3479, DOI 10.1016/j.biomaterials.2010.01.074
Cheng YT, 2005, APPL PHYS LETT, V86, DOI [10.1063/1.1923750, 10.1063/1.1895487]
Choi JS, 2008, BIOMATERIALS, V29, P2899, DOI 10.1016/j.biomaterials.2008.03.031

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