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pH and redox-responsive mixed micelles for enhanced intracellular drug release

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WOS被引频次:38
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成果类型:
期刊论文
作者:
Cai, Mengtan;Zhu, Kun;Qiu, Yongbin;Liu, Xinrong;Chen, Yuanwei*;Luo, Xianglin
通讯作者:
Chen, Yuanwei
作者机构:
[Chen, Yuanwei; Luo, Xianglin; Cai, Mengtan; Qiu, Yongbin; Zhu, Kun] Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China.
[Liu, Xinrong] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China.
[Luo, Xianglin] Sichuan Univ, State Key Lab Polymer Mat & Engn China, Chengdu 610065, Peoples R China.
通讯机构:
[Chen, Yuanwei] Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China.
语种:
英文
关键词:
pH Sensitive;Redox sensitive;Dual response;Drug delivery;Curcumin
期刊:
Colloids and Surfaces B: Biointerfaces
ISSN:
0927-7765
年:
2014
卷:
116
页码:
424-431
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:生物学与生物化学;WOS学科类别:Biophysics;Chemistry, Physical;Materials Science, Biomaterials
入藏号:
WOS:000335706100056;EI:20140817364168
基金类别:
National Natural Science Foundation of China [51073103, 51273125]
机构署名:
本校为其他机构
院系归属:
生命科学与工程学院
摘要:
In order to prepare pH and redox sensitive micelles, amphiphilic copolymers of poly (epsilon-caprolactone)-b-poly(2-(diethylamino) ethyl methacrylate) (PCL-PDEA) and disulfide-linked poly(ethyl glycol)-poly(epsilon-caprolactone) (mPEG-SS-PCL) were synthesized. The double-sensitive micelles were prepared simply by solvent-evaporating method with the mixed two copolymers. The pH sensitivity of the mixed micelles was confirmed by the change of micelle diameter/diameter distribution measured by dynamic lighting scattering (DLS) and the redox sensitivity of the mixed micelles was testified by the change of micellar morphous observed by scanning electron microscope (SEM). In vitro drug release showed that drug-loaded mixed micelles (mass ratio 5:5) could achieve above 90% of drug release under low pH and reducing condition within 10 h. Moreover, the drug-loaded mixed micelles (mass ratio 5:5) showed the largest cellular toxicity compared with other drug-loaded micelles, while blank mixed micelles exhibited no toxicity. These results meant that the mixed micelles composed by the two amphiphilic copolymers can enhance intracellular drug release. It is concluded that the newly developed mixed micelles can serve as a potential drug delivery system for anticancer drugs. (C) 2014 Elsevier B.V. All rights reserved.

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