版权说明 帮助中心
首页 > 成果 > 详情

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

SCI-EEIMedline
WOS被引频次:29
认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Zhang, Zhao;Qu, Qianqian;Li, Jinrong;Zhou, Shaobing*
通讯作者:
Zhou, Shaobing
作者机构:
[Zhang, Zhao; Qu, Qianqian; Zhou, Shaobing] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Peoples R China.
[Zhou, Shaobing; Li, Jinrong] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China.
通讯机构:
[Zhou, Shaobing] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Peoples R China.
语种:
英文
关键词:
biodegradable;block copolymers;drug delivery systems;micelles;poly(ε‐caprolactone)
期刊:
Macromolecular Bioscience
ISSN:
1616-5195
年:
2013
卷:
13
期:
6
页码:
789-798
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:生物学与生物化学;WOS学科类别:Biochemistry & Molecular Biology;Materials Science, Biomaterials;Polymer Science
入藏号:
WOS:000320590500015;EI:20132716465825
基金类别:
National Basic Research Program of China (973 Program) [2012CB933600]; National Natural Science Foundation of China [30970723, 51173150]; National Key Project of Scientific and Technical Supporting Programs; MSTC [2012BAI17B06]; Fundamental Research Funds for the Central Universities [SWJTU11ZT10]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
Fluorescein isothiocyanate (FITC), a fluorescent probe, is coupled to amphiphilic monomethoxy poly(ethylene glycol)‐block‐poly(ε‐caprolactone) (mPEG‐PCL) copolymers. FITC‐labeled mPEG‐PCL copolymers self‐assemble into micelles through the solvent evaporation method. The cellular internalization is examined using fluorescence microscopy on incubation of NIH‐3T3 fibroblasts with micelles or free FITC solution. The effect of the hydrophilic/hydrophobic ratio on the endocytosis mechanisms is evaluated by fluorescence microscopy on culturing of human hepatoblastoma cells and human umbilical vein endothelial cells, individually, mixed with the micelles holding the same parameters including micelle size, shape, and surface charges.
参考文献:
Barreto JA, 2011, ADV MATER, V23, pH18, DOI 10.1002/adma.201100140
Cai SS, 2007, PHARM RES, V24, P2099, DOI 10.1007/s11095-007-9335-z
Champion JA, 2007, J CONTROL RELEASE, V121, P3, DOI 10.1016/j.jconrel.2007.03.022
Chen T, 2012, ADV HEALTHC MATER, V1, P214, DOI 10.1002/adhm.201100040
Du ZX, 2007, MACROMOLECULES, V40, P7633, DOI 10.1021/ma070977p

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com