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Size Changeable Nanocarriers with Nuclear Targeting for Effectively Overcoming Multidrug Resistance in Cancer Therapy

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WOS被引频次:82
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成果类型:
期刊论文
作者:
Guo, Xing;Wei, Xiao;Jing, Yuting;Zhou, Shaobing*
通讯作者:
Zhou, Shaobing
作者机构:
[Guo, Xing; Wei, Xiao; Zhou, Shaobing] Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China.
[Jing, Yuting; Zhou, Shaobing] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China.
通讯机构:
[Zhou, Shaobing] Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China.
语种:
英文
关键词:
cancer therapy;multidrug resistance;nanocarriers;nuclear targeting;reductive‐sensitive materials
期刊:
Advanced Materials
ISSN:
0935-9648
年:
2015
卷:
27
期:
41
页码:
6450-6456
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:材料科学;WOS学科类别:Chemistry, Multidisciplinary;Chemistry, Physical;Materials Science, Multidisciplinary;Nanoscience & Nanotechnology;Physics, Applied;Physics, Condensed Matter
入藏号:
WOS:000364343700021;EI:20154501508474;PMID:26401989
基金类别:
National Basic Research Program of China (973 Program) [2012CB933600]; National Natural Science Foundation of China [30970723, 51173150, 51373138, 21574105]; Construction Program for Innovative Research Team of University in Sichuan Province [14TD0050]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
A size changeable polymer micelle system with a dual shell, which increases in size under acidic pH conditions and is altered to smaller micelles, triggered by intracellular glutathione (GSH), is successfully developed. It is capable of direct delivering anticancer drugs to the nucleus of multidrug resistance (MDR) tumor cells for highly effective combating of drug resistant breast cancer. ©2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
参考文献:
Abe Y, 1996, BRIT J CANCER, V74, P1929, DOI 10.1038/bjc.1996.655
BOUSSIF O, 1995, P NATL ACAD SCI USA, V92, P7297, DOI 10.1073/pnas.92.16.7297
Cabral H, 2011, NAT NANOTECHNOL, V6, P815, DOI [10.1038/NNANO.2011.166, 10.1038/nnano.2011.166]
Davis ME, 2008, NAT REV DRUG DISCOV, V7, P771, DOI 10.1038/nrd2614
Guo X, 2014, CHEM MATER, V26, P4405, DOI 10.1021/cm5012718

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