版权说明 帮助中心
首页 > 成果 > 详情

Size Changeable Nanocarriers with Nuclear Targeting for Effectively Overcoming Multidrug Resistance in Cancer Therapy

Medline
WOS被引频次:90
认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Guo, Xing;Wei, Xiao;Jing, Yuting;Zhou, Shaobing*
通讯作者:
Zhou, Shaobing
作者机构:
[Guo, Xing; Wei, Xiao; Zhou, Shaobing] Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P.R. China
[Jing, Yuting; Zhou, Shaobing] School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P.R. China
通讯机构:
[Zhou, Shaobing] Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China.
语种:
英文
关键词:
cancer therapy;multidrug resistance;nanocarriers;nuclear targeting;reductive‐sensitive materials
期刊:
Advanced Materials
ISSN:
1521-4095
年:
2015
卷:
27
期:
41
页码:
6450-6456
文献类别:
WOS:Article;PUBMED:Journal Article
入藏号:
基金类别:
National Basic Research Program of China (973 Program) [2012CB933600]; National Natural Science Foundation of China [30970723, 51173150, 51373138, 21574105]; Construction Program for Innovative Research Team of University in Sichuan Province [14TD0050]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
A size changeable polymer micelle system with a dual shell, which increases in size under acidic pH conditions and is altered to smaller micelles, triggered by intracellular glutathione (GSH), is successfully developed. It is capable of direct delivering anticancer drugs to the nucleus of multidrug resistance (MDR) tumor cells for highly effective combating of drug resistant breast cancer.
参考文献:
Abe Y, 1996, BRIT J CANCER, V74, P1929, DOI 10.1038/bjc.1996.655
BOUSSIF O, 1995, P NATL ACAD SCI USA, V92, P7297, DOI 10.1073/pnas.92.16.7297
Cabral H, 2011, NAT NANOTECHNOL, V6, P815, DOI [10.1038/NNANO.2011.166, 10.1038/nnano.2011.166]
Davis ME, 2008, NAT REV DRUG DISCOV, V7, P771, DOI 10.1038/nrd2614
Guo X, 2014, CHEM MATER, V26, P4405, DOI 10.1021/cm5012718

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com