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Actively targeted delivery of anticancer drug to tumor cells by redox-responsive star-shaped micelles

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WOS被引频次:95
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成果类型:
期刊论文
作者:
Shi, Chunli;Guo, Xing;Qu, Qianqian;Tang, Zhaomin;Wang, Yi;Zhou, Shaobing*
通讯作者:
Zhou, Shaobing
作者机构:
[Wang, Yi; Guo, Xing; Tang, Zhaomin; Qu, Qianqian; Zhou, Shaobing; Shi, Chunli] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Peoples R China.
[Zhou, Shaobing; Shi, Chunli] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China.
通讯机构:
[Zhou, Shaobing] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China.
语种:
英文
关键词:
Redox-responsive;Star-shaped;Nanocarrier;Drug delivery;Tumor targeting
期刊:
Biomaterials
ISSN:
0142-9612
年:
2014
卷:
35
期:
30
页码:
8711-8722
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:材料科学;WOS学科类别:Engineering, Biomedical;Materials Science, Biomaterials
入藏号:
WOS:000340849600025;EI:20143118002586
基金类别:
National Basic Research Program of China (973 Program) [2012CB933600]; National Natural Science Foundation of China [51173150, 51373138]; Research Fund for the Doctoral Program of Higher Education of China [20120184110029]; Construction Program for Innovative Research Team of University in Sichuan Province [14TD0050]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
In cancer therapy nanocargos based on star-shaped polymer exhibit unique features such as better stability, smaller size distribution and higher drug capacity in comparison to linear polymeric micelles. In this study, we developed a multifunctional star-shaped micellar system by combination of active targeting ability and redox-responsive behavior. The star-shaped micelles with good stability were self-assembled from four-arm poly(epsilon-caprolactone)-poly(ethylene glycol) copolymer. The redox-responsive behaviors of these micelles triggered by glutathione were evaluated from the changes of micellar size, morphology and molecular weight. In vitro drug release profiles exhibited that in a stimulated normal physiological environment, the redox-responsive star-shaped micelles could maintain good stability, whereas in a reducing and acid environment similar with that of tumor cells, the encapsulated agent was promptly released. In vitro cellular uptake and subcellular localization of these micelles were further studied with confocal laser scanning microscopy and flow cytometry against the human cervical cancer cell line HeLa. In vivo and ex vivo DOX fluorescence imaging displayed that these FA-functionalized star-shaped micelles possessed much better specificity to target solid tumor. Both the qualitative and quantitative results of the antitumor effect in 4T1 tumor-bearing BALB/c mice demonstrated that these redox-responsive star-shaped micelles have a high therapeutic efficiency to artificial solid tumor. Therefore, the multifunctional star-shaped micelles are a potential platform for targeted anticancer drug delivery. (C) 2014 Elsevier Ltd. All rights reserved.
参考文献:
Allen TM, 2004, SCIENCE, V303, P1818, DOI 10.1126/science.1095833
Allen TM, 2002, NAT REV CANCER, V2, P750, DOI 10.1038/nrc903
Ashley CE, 2011, NAT MATER, V10, P389, DOI [10.1038/NMAT2992, 10.1038/nmat2992]
Bae Y, 2003, ANGEW CHEM INT EDIT, V42, P4640, DOI 10.1002/anie.200250653
Bosman AW, 1999, CHEM REV, V99, P1665, DOI 10.1021/cr970069y

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