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Target-Specific Cellular Uptake of Folate-Decorated Biodegradable Polymer Micelles

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WOS被引频次:32
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成果类型:
期刊论文
作者:
Zhou, Qi;Guo, Xing;Chen, Tao;Zhang, Zhao;Shao, Shijun;Luo, Chao;Li, Jinrong;Zhou, Shaobing*
通讯作者:
Zhou, Shaobing
作者机构:
[Zhou, Qi; Guo, Xing; Chen, Tao; Zhang, Zhao; Zhou, Shaobing] SW Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Peoples R China.
[Luo, Chao; Zhou, Shaobing; Li, Jinrong; Shao, Shijun] SW Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China.
通讯机构:
[Zhou, Shaobing] SW Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Peoples R China.
语种:
英文
期刊:
The journal of physical chemistry. B
ISSN:
1520-6106
年:
2011
卷:
115
期:
43
页码:
12662–12670
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:化学;WOS学科类别:Chemistry, Physical
入藏号:
WOS:000296169900039;EI:20114414474386
基金类别:
National Natural Science Foundation of China [30970723, 51173150]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
For cancer therapy, folate (FA) and β-cyclodextrin (β-CD) decorated micelles based on the biodegradable pluronic F127-b-poly(- caprolactone) copolymer were fabricated. These micelles were measured by dynamic light scattering measurements and atomic force microscopy. The in vitro release of doxorubicin hydrochloride (DOX-HCl) from the biodegradable polymer micelles was performed in a phosphate-buffered saline solution at pH 7.4 and acetate buffer solution at pH 5.0 at the temperatures of 4, 25, and 37 °C, and the results show that the release was obviously influenced by the pH and temperature. The material cytotoxicity and the tumor cell growth inhibition assays of DOX-HCl-loaded micelles were studied with the human hepatoblastoma cell line (HepG2), the lung epithelial cancer cell line (A549), and human nasopharyngeal epidermoid carcinoma cells (KB) and fibroblast normal cells using fluorescence microscopy as well as confocal laser scanning microscopy. The cellular uptake was quantitatively analyzed to further evaluate the active targeting behaviors of the micelles by flow cytometry. These quantitative and qualitative results of cellular uptake of the micelles provide evidence for the different targeting efficiencies of FA decoration for HepG2, KB, and A549 tumor cells as well as fibroblast normal cells. It also suggested that FA- and β-CD-decorated doxorubicin-loaded micelles may have great potential as nanocarriers for targeted drug delivery. ©2011 American Chemical Society.
参考文献:
Bae KH, 2007, BIOMACROMOLECULES, V8, P650, DOI 10.1021/bm0608939
Canal F, 2010, J CONTROL RELEASE, V146, P388, DOI 10.1016/j.jconrel.2010.05.027
Chen S, 2008, BIOMACROMOLECULES, V9, P2578, DOI 10.1021/bm800371n
Cho SY, 2009, MACROMOLECULES, V42, P4484, DOI 10.1021/ma900567n
Crupi V, 2009, J PHYS CHEM B, V113, P11032, DOI 10.1021/jp810546h

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