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Controlled green tea polyphenols release from electrospun PCL/MWCNTs composite nanofibers

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WOS被引频次:68
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成果类型:
期刊论文
作者:
Shao, Shijun;Li, Long;Yang, Guang;Li, Jingrong;Luo, Chao;Gong, Tao;Zhou, Shaobing*
通讯作者:
Zhou, Shaobing
作者机构:
[Yang, Guang; Gong, Tao; Li, Long; Zhou, Shaobing; Shao, Shijun] SW Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China.
[Luo, Chao; Zhou, Shaobing; Li, Jingrong; Shao, Shijun] SW Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China.
通讯机构:
[Zhou, Shaobing] SW Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China.
语种:
英文
关键词:
Electrospinning;Biodegradable;Nanofibers;Controlled release
期刊:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN:
0378-5173
年:
2011
卷:
421
期:
2
页码:
310-320
文献类别:
WOS:Article
所属学科:
ESI学科类别:药理学&毒理学;WOS学科类别:Pharmacology & Pharmacy
入藏号:
WOS:000298527400015;PMID:21983092
基金类别:
National Natural Science Foundation of China [30970723]; Ministry of Education of China [NCET-07-0719]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
Poly(epsilon-caprolactone)/multi-walled carbon nanotubes (PCL/MWCNTs) composite nanofibers with various content of green tea polyphenols (GTP) were successfully fabricated via an electrospinning technology to maintain the chemical structural stability of GTP. The non-covalent interaction between MWCNTs and GTP was measured by UV-vis spectrophotometer and FT-IR. The topographical features of the nanofibers were characterized by scanning electron microscopy (SEM). The dispersibility of MWCNTs and the distribution of GTP in nanofibers were observed by transmission electron microscopy (TEM) and laser scanning confocal microscope (LSCM), respectively. In vitro degradation was also characterized in terms of the morphological change and the mass loss of the nanofiber meshes. In vitro GTP release behavior was investigated in phosphate-buffered solution (PBS) at 37 degrees C. Alamar blue assays were performed to estimate the cytotoxicity of the nanofibers with normal osteoblast cells and the antiproliferative effects to A549 and Hep G2 tumor cells. The results exhibited that the GIP-loaded composite nanofibers possessed a significant inhibition effect to tumor cells. Therefore, GTP, as a multifunctional drug, encapsulated into polymer composite nanofibers, must have broad application prospects in cancer therapy. (C) 2011 Elsevier B.V. All rights reserved.
参考文献:
Abarrategi A, 2008, BIOMATERIALS, V29, P94, DOI 10.1016/j.biomaterials.2007.09.021
Agarwal S, 2008, POLYMER, V49, P5603, DOI 10.1016/j.polymer.2008.09.014
Ahmad N, 2000, ARCH BIOCHEM BIOPHYS, V376, P338, DOI 10.1006/abbi.2000.1742
Babich H, 2005, TOXICOL IN VITRO, V19, P231, DOI 10.1016/j.tiv.2004.09.001
Bhattarai SR, 2004, BIOMATERIALS, V25, P2595, DOI 10.1016/j.biomaterials.2003.09.043

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