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Hydroxyapatite nucleation and growth mechanism on electrospun fibers functionalized with different chemical groups and their combinations

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WOS被引频次:98
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成果类型:
期刊论文
作者:
Cui, Wenguo;Li, Xiaohong*;Xie, Chengying;Zhuang, Huihui;Zhou, Shaobing;Weng, Jie
通讯作者:
Li, Xiaohong
作者机构:
[Li, Xiaohong; Zhuang, Huihui; Cui, Wenguo; Zhou, Shaobing; Weng, Jie] SW Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China.
[Cui, Wenguo] Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai 200030, Peoples R China.
[Li, Xiaohong; Xie, Chengying] SW Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China.
通讯机构:
[Li, Xiaohong] SW Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China.
语种:
英文
关键词:
Electrospun fibers;Functional groups;Hydroxyapatite nucleation;Growth mechanism;Biological evaluation
期刊:
Biomaterials
ISSN:
0142-9612
年:
2010
卷:
31
期:
17
页码:
4620-4629
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:材料科学;WOS学科类别:Engineering, Biomedical;Materials Science, Biomaterials
入藏号:
WOS:000277899500002;EI:20101612871793
基金类别:
National Natural Science Foundation of China [20774075]; MOE [NECT-06-0801]; MSTC [2006BAI16B01]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
Controlled nucleation and growth of hydroxyapatite (HA) crystals on electrospun fibers should play important roles in fabrication of composite scaffolds for bone tissue engineering, but no attempt has been made to clarify the effects of chemical group densities and the cooperation of two and more groups on the biomineralization process The aim of the current study was to investigate into HA nucleation and growth on electrospun poly(x-lactide) fibers functionalized with carboxyl, hydroxyl and amino groups and their combinations. Electrospun fibers with higher densities of carboxyl groups, combination of hydroxyl and carboxyl groups with the ratio of 3/7, and combination of amino, hydroxyl and carboxyl groups with the ratio of 2/3/5 were favorable for HA nucleation and growth, resulting in higher content and lower crystal size of formed HA. Carboxyl groups were initially combined with calcium ions through electrostatic attraction, and the introduction of hydroxyl groups could modulate the distance between carboxyl groups The introduction of amino groups may lead to the inner ionic bonding with carboxyl groups, but can accelerate phosphate ions to form HA through a chelate ring with the calcium ion and carbonyl oxygen The biological evaluation indicated that the mineralized scaffolds acted as an excellent cell support to maintain desirable cell substrate interactions, to provide favorable conditions for cell proliferation and to stimulate the osteogenic differentiation (C) 2010 Elsevier Ltd. All rights reserved.
参考文献:
Arima Y, 2007, BIOMATERIALS, V28, P3074, DOI 10.1016/j.biomaterials.2007.03.013
Chan T. -W, 1997, INT J ARTIFICIAL INT, V8, P1
Chen JL, 2006, J BIOMED MATER RES A, V79A, P307, DOI 10.1002/jbm.a.30799
Cui FZ, 2007, MAT SCI ENG R, V57, P1, DOI 10.1016/j.mser.2007.04.001
CUI W, 2007, J APPL POLYM SCI, V5, P100

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