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Osteoblast function on electrically conductive electrospun PLA/MWCNTs nanofibers

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WOS被引频次:154
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成果类型:
期刊论文
作者:
Shao, Shijun;Zhou, Shaobing*;Li, Long;Li, Jinrong;Luo, Chao;Wang, Jianxin;Li, Xiaohong;Weng, Jie
通讯作者:
Zhou, Shaobing
作者机构:
[Luo, Chao; Zhou, Shaobing; Li, Jinrong; Shao, Shijun] SW Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China.
[Li, Xiaohong; Li, Long; Zhou, Shaobing; Wang, Jianxin; Weng, Jie] SW Jiaotong Univ, Key Lab Adv Technol Mat, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China.
通讯机构:
[Zhou, Shaobing] SW Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China.
语种:
英文
关键词:
Biodegradable;Carbon nanotube;Electrospinning;Conductive;Nanofiber
期刊:
Biomaterials
ISSN:
0142-9612
年:
2011
卷:
32
期:
11
页码:
2821-2833
文献类别:
WOS:Article;PUBMED:Journal Article
入藏号:
基金类别:
National Natural Science Foundation of China [30970723]; Ministry of Education of China [NCET-07-0719]; Sichuan Prominent Young Talent Program [08ZQ026-040]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
The electrospinning process was utilized successfully to fabricate the random oriented and aligned electrically conductive nanofibers of biodegradable poly-DL-lactide (PLA) in which multiwalled carbon nanotubes (MWCNTs) were embedded. The topographical features of the composite nanofibers were characterized by SEM. The dispersion and alignment of MWCNTs in nanofiber matrix were observed by TEM. The in vitro degradation was characterized in terms of the morphological change, the mass loss and the reduction of polymer molecular weight as well as the decrease of pH value of degradation media. In particular, these conductive nanofiber meshes offered a unique system to study the synergistic effect of topographic cues and electrical stimulation on osteoblasts outgrowth as a way of exploring their potential application in bone tissue engineering. The results of obsteoblasts assay unstimulated showed that the aligned nanofibers as topographic cues could enhance the extension and direct the outgrowth of obsteoblasts better than random fibers. In the presence of direct current (DC) of 100 mu A, the obsteoblasts on all samples grew along the electrical current direction. The cellular elongation and proliferation were mainly dependent on the electrical stimulation whereas the topographical features played a minor role in them. Therefore, electrical stimulation with an appropriate DC value imparted on conductive substrate had great potential in application of bone tissue engineering. (C) 2011 Elsevier Ltd. All rights reserved.
参考文献:
Abarrategi A, 2008, BIOMATERIALS, V29, P94, DOI 10.1016/j.biomaterials.2007.09.021
Aboudzadeh N, 2010, J BIOMED MATER RES A, V94A, P137, DOI 10.1002/jbm.a.32673
Au HTH, 2007, BIOMATERIALS, V28, P4277, DOI 10.1016/j.biomaterials.2007.06.001
BASEDOW AM, 1978, MAKROMOL CHEM, V179, P2565
Britland S, 1996, EXP CELL RES, V226, P31, DOI 10.1006/excr.1996.0199

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