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In Vitro Investigation of Enhanced Hemocompatibility and Endothelial Cell Proliferation Associated with Quinone-Rich Polydopamine Coating

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成果类型:
期刊论文
作者:
Luo, Rifang;Tang, Linlin;Zhong, Si;Yang, Zhilu;Wang, Jin;Weng, Yajun;Tu, Qiufen;Jiang, Chongxi;Huang, Nan
通讯作者:
Wang, J.(jinxxwang@263.net)
作者机构:
[Wang, Jin; Jiang, Chongxi; Luo, Rifang; Weng, Yajun; Tu, Qiufen; Huang, Nan; Yang, Zhilu; Tang, Linlin] Key Lab of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China
[Zhong, Si] School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
通讯机构:
[Wang, Jin] Southwest Jiaotong Univ, Educ Minist, Key Lab Adv Technol Mat, Chengdu 610031, Peoples R China.
语种:
英文
关键词:
polydopamine;surface modification;hemocompatibility;vascular stent;endothelialization;thermal
期刊:
ACS Applied Materials and Interfaces
ISSN:
1944-8244
年:
2013
卷:
5
期:
5
页码:
1704-1714
文献类别:
WOS:Article;EI:Journal article (JA);PUBMED:Journal Article
入藏号:
WOS:000316308100025;EI:20131216134574
基金类别:
National Natural Science Foundation of China [51173149]; Ministry of Scientific and Technical Project of China (Key Basic Research Project) [2011CB606204]; Natural Science Foundation for the Youth of China [31000426, 30900295]; Fundamental Research Funds for the Central Universities [SWJTU11CX057]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
Recent investigations have demonstrated that polydopamine (PDA)-modified surfaces were beneficial to the proliferation of endothelial cells (ECs). In this work, PDA coated 316L stainless steels (316L SS) were thermally treated at 50, 100, and 150 C respectively (hereafter designated as Th50, Th100, and Th150) and consequently produced diverse surface chemical components. In vitro hemocompatibility and vascular cell-material interactions with ECs and smooth muscle cells (SMCs) affected by surface characteristics have been investigated. The Th150, rich in quinone, showed the best hemocompatibility and could effectively inhibit platelet adhesion, activation, and fibrinogen conformation transition. The polydopamine-modified surfaces were found to induce dramatic cell-material interaction with enhanced ECs proliferation, viability and migration, release of nitric oxide (NO), and reduced SMCs proliferation. The inhibitory effect of SMCs proliferation might be associated with the surface catechol content. The coating on Th150 showed a good resistance to the deformation of compression and expansion of vascular stents. These results effectively suggested that the Th150 coating might be promising when served as a stent coating platform. ©2013 American Chemical Society.
参考文献:
Adali M.A., 2010, BIOTECHNOL ADV, V28, P119
Anselme K, 2000, BIOMATERIALS, V21, P667, DOI 10.1016/S0142-9612(99)00242-2
Chen HM, 2009, CANCER LETT, V286, P161, DOI 10.1016/j.canlet.2009.05.040
Chen ZY, 2000, ACTA PHARMACOL SIN, V21, P835
Cheng XW, 2005, ARTERIOSCL THROM VAS, V25, P1864, DOI 10.1161/01.ATV.0000179675.49619.9b

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