版权说明 帮助中心
首页 > 成果 > 详情

Controlled dual delivery of BMP-2 and dexamethasone by nanoparticle-embedded electrospun nanofibers for the efficient repair of critical-sized rat calvarial defect

SCI-EEIMedline
WOS被引频次:108
认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Li, Long;Zhou, Guangliang;Wang, Yi;Yang, Guang;Ding, Shan;Zhou, Shaobing*
通讯作者:
Zhou, Shaobing
作者机构:
[Wang, Yi; Yang, Guang; Li, Long; Zhou, Shaobing] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minister Educ, Chengdu 610031, Peoples R China.
[Zhou, Guangliang] Southwest Jiaotong Univ, Sch Mech Engn, Chengdu 610031, Peoples R China.
[Ding, Shan; Zhou, Shaobing] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China.
通讯机构:
[Zhou, Shaobing] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minister Educ, Chengdu 610031, Peoples R China.
语种:
英文
关键词:
Nanofiber;Electrospinning;Critical bone defect;Nanoparticle;Drug delivery;Tissue engineering
期刊:
Biomaterials
ISSN:
0142-9612
年:
2015
卷:
37
页码:
218-229
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:材料科学;WOS学科类别:Engineering, Biomedical;Materials Science, Biomaterials
入藏号:
WOS:000346541100021;EI:20150600502994
基金类别:
National Basic Research Program of China (973 Program) [2012CB933600]; National Natural Science Foundation of China [51173150, 51373138]; National Key Project of Scientific and Technical Supporting Programs - MSTC [2012BAI17B06]; Construction Program for Innovative Research Team of University in Sichuan Province [14TD0050]; Doctoral Innovation Funds of Southwest Jiaotong University; Fundamental Research Funds for the Central Universities [SWJTU11ZT10, 2682013CX001]
机构署名:
本校为第一且通讯机构
院系归属:
机械工程学院
材料科学与工程学院
生命科学与工程学院
摘要:
There is an urgent need to develop biomimetic bone tissue engineering scaffolds for the repair of criticalsized calvarial defect. In this study, we developed a new nanoparticle-embedded electrospun nanofiber scaffold for the controlled dual delivery of BMP-2 and dexamethasone (DEX). The scaffold was achieved by (1) the encapsulation of BMP-2 into bovine serum albumin (BSA) nanoparticles to maintain the bioactivity of BMP-2 and (2) the co-electrospinning of the blending solution composed of the BSA nanoparticles, DEX and the poly(epsilon-caprolactone)-co-poly(ethylene glycol) (PCE) copolymer. The in vitro studies showed that the bioactivity of DEX and BMP-2 was preserved in the dual-drug-loaded nanofiber scaffold, and a sequential release pattern in which most of the DEX was released in the original eight days and the BMP-2 release lasted up to 35 days was achieved. The in vitro osteogenesis study demonstrated that the drug-loaded groups exhibited a strong ability to induce differentiation toward osteoblasts. In vivo osteogenesis studies also revealed that the degrees of repair of rat calvarial defect achieved with the drug-loaded nanofiber scaffolds were significantly better than those obtained with the blank materials; in particular, the dual-drug-loaded nanofiber scaffold manifested the best repair efficacy due to a synergistic effect of BMP-2 and DEX. Therefore, the dual-drug-loaded nanofiber scaffold is deemed a strong potential candidate for the repair of bone defects in bone tissue engineering. (C) 2014 Elsevier Ltd. All rights reserved.
参考文献:
Amini Ami R., 2012, Critical Reviews in Biomedical Engineering, V40, P363
Ben-David D, 2013, BIOMATERIALS, V34, P2902, DOI 10.1016/j.biomaterials.2013.01.035
Burg KJL, 2000, BIOMATERIALS, V21, P2347, DOI 10.1016/S0142-9612(00)00102-2
Cao LY, 2014, BIOMATERIALS, V35, P2730, DOI 10.1016/j.biomaterials.2013.12.028
Cao LY, 2014, BIOMATERIALS, V35, P684, DOI 10.1016/j.biomaterials.2013.10.005

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com