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Pyrrolizidine alkaloids from Liparis nervosa with inhibitory activities against LPS-induced NO production in RAW264.7 macrophages

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WOS被引频次:26
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成果类型:
期刊论文
作者:
Huang, Shuai;Zhou, Xian-li*;Wang, Cui-juan;Wang, You-song;Xiao, Feng;Shan, Lian-hai;Guo, Zhi-yun;Weng, Jie
通讯作者:
Zhou, Xian-li
作者机构:
[Wang, You-song; Xiao, Feng; Shan, Lian-hai; Huang, Shuai; Wang, Cui-juan; Guo, Zhi-yun; Zhou, Xian-li] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China.
[Huang, Shuai; Weng, Jie] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China.
通讯机构:
[Zhou, Xian-li] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China.
语种:
英文
关键词:
Liparis nervosa;Orchidaceae;Pyrrolizidine alkaloids;Nervosine;Nervogenic acid derivatives;NO production inhibitor
期刊:
Phytochemistry
ISSN:
0031-9422
年:
2013
卷:
93
页码:
154-161
文献类别:
WOS:Article
所属学科:
ESI学科类别:植物学&动物科学;WOS学科类别:Biochemistry & Molecular Biology;Plant Sciences
入藏号:
基金类别:
Ministry of Education [NCET-08-0820]; Fundamental Research Funds for Central Universities [SWJTU2010ZT09]; National Natural Science Foundation of China [21142004]
机构署名:
本校为第一且通讯机构
院系归属:
材料科学与工程学院
生命科学与工程学院
摘要:
Six pyrrolizidine alkaloids were isolated from the whole herb of Liparis nervosa together with two previously known ones. Their structures were elucidated by extensive spectroscopic analyses and chemical reactions. The cytotoxicity of the isolates was evaluated against A549, HepG2, and MCF-7 human cancer cell lines; however, no significant growth inhibition was observed. All compounds were evaluated for the inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, and most significantly inhibited NO production with IC50 values in the range of 2.16-38.25 mu M. (C) 2013 Elsevier Ltd. All rights reserved.
参考文献:
DENIZOT F, 1986, J IMMUNOL METHODS, V89, P271, DOI 10.1016/0022-1759(86)90368-6
Flores N, 2008, J NAT PROD, V71, P1538, DOI 10.1021/np800104p
GALINOVSKY F, 1949, MONATSH CHEM, V80, P550, DOI 10.1007/BF00899158
Ikeda Y, 2005, J NAT PROD, V68, P572, DOI 10.1021/np049650x
Koulman A, 2008, PHYTOCHEMISTRY, V69, P1927, DOI 10.1016/j.phytochem.2008.03.017

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