Hierarchically structured polymer fibers encompassing 1-D, 2-D, and 3-D structures with at least one dimension nano- to micro-meters in size have recently received an increasing amount of attention due to their vast potential in such applications as sensing, medicine, energy storage. This review summarizes advancements in the last ten years in the design and fabrication of hierarchically structured polymer fibers via electrospinning technologies, including a diversity of electrospinning devices and electrospinning parameters using various polymers. These well-defined, multilevel structures enable the fibers to be used more effectively in applications in the biomedical field, such as drug delivery, tissue engineering, and diagnostics. This review can provide a better understanding of the relationships between the structure and functionality of polymer fibers for further biomedical applications. (C) 2017 Elsevier B.V. All rights reserved.
Nanoparticle-based systems explore not only the delivery efficacy of drugs or contrast agents, but also additional capabilities like reducing the systemic toxicity, especially during cancer chemotherapy. Since some of the noble metal nanoparticles exhibit the catalysis properties which can scavenge the reactive oxygen species (ROS), they can be used as a promising drug delivery platform for reducing the oxidative stress damage in normal tissues caused by some chemotherapy drugs. Herein, in this study, we construct porous Au@Pt nanoparticles and further explore the properties of porous Au@Pt nanoparticles in relieving the oxidative stress damage as well as in tumor growth inhibition by chemo-photothermal co-therapy. The tunable surface pore structure of Au@Pt nanoparticle provides space for Doxorubicin (DOX) loading. cRGD peptide modification enable the DOX-loaded Au@Pt nanoparticles to improve drug delivery properties. The constructed nanocarrier (DOX/Au@Pt-cRGD) shows controlled drug release behavior. Meanwhile, the absorbance peak of the Au@Pt structure in the near-infrared (NIR) portion provides the capacity for in vivo photoacoustic imaging and the high photoconversion efficiency, which make Au@Pt nanoparticle a suitable carrier for photothermal therapy (PTT). Combined with chemotherapy, the nanosystem DOX/Au@Pt-cRGD shows enhanced anticancer therapeutic effects. More importantly, ROS-scavenging activity of Au@Pt alleviates the DOX-induced oxidative stress damage, especially the cardiomyopathy during chemotherapy. Herein, this nanosystem DOX/Au@Pt-cRGD could be explored as reactive oxygen scavenger and drug delivery system for side effects relieving chemo-photothermal combinational therapy.
[Xiao, Yao; Chen, Lijuan; Qian, Zhiyong; Peng, Jinrong; Shi, Kun; Tang, Xichuan] Sichuan Univ, West China Med Sch, State Key Lab Biotherapy, West China Hosp, Chengdu 610041, Sichuan, Peoples R China.;[Xiao, Yao; Chen, Lijuan; Qian, Zhiyong; Peng, Jinrong; Shi, Kun; Tang, Xichuan] Collaborat Innovat Ctr, Chengdu 610041, Sichuan, Peoples R China.;[Tan, Liwei] Southwest Jiaotong Univ, Coll Med, Chengdu 610031, Sichuan, Peoples R China.;[Li, Wenting] Sichuan Univ, West China Univ Hosp 2, Dept Pharm, Chengdu 610041, Sichuan, Peoples R China.;[Yang, Qian] Chengdu Med Coll, Key Coll Lab Sichuan Prov Specif Struct Small Mol, Sch Pharm, Chengdu 610500, Sichuan, Peoples R China.
[Qian, Zhiyong] Sichuan Univ, West China Med Sch, State Key Lab Biotherapy, West China Hosp, Chengdu 610041, Sichuan, Peoples R China.;[Qian, Zhiyong] Collaborat Innovat Ctr, Chengdu 610041, Sichuan, Peoples R China.
Enhancing the heat-sensitivity of tumor cells provides an alternative solution to maintaining the therapeutic outcome of photothermal therapy(PTT). In this study, we constructed a therapeutic system, which was composed of methoxy-polyethylene-glycol-coated-gold-nanorods(MPEG-AuN R) and VER-155008-micelles, to evaluate the effect of VER-155008 on the sensitivity of tumor cells to heat, and further investigate the therapeutic outcome of MPEG-AuN R mediated PTT combined with VER-155008-micelles. VER-155008-micelles downregulate the expression of heat shock proteins and attenuate the heat-resistance of tumor cell. The survival of HCT116 cells treated with VER-155008-micelles under 45 ℃ is equal to that treated with high temperature hyperthermia(55 ℃) in vitro. Furthermore, we proved either the MPEG-AuN R or VER-155008-micelles can be accumulate in the tumor site by photoacoustic imaging and fluorescent imaging. In vivo anti-cancer evaluation showed that tumor size remarkably decreased(smaller than 100 mm~3 or vanished) when treated with combing 45℃ mild PTT system, which contrasted to the tumor size when treated with individual 45℃ mild PTT(around 500nm~3) or normal saline as control(larger than 2000 nm~3). These results proved that the VER-155008-micelles can attenuate the heat-resistance of tumor cells and enhance the therapeutic outcome of mild-temperature photothermal therapy.